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Jeff Halsey is an eccentric pre-teen whose best friend is a clever girl named Katie. When Jeff discovers that his right hand has the ability to talk, he must accommodate his new companion (named Guy, short for "right-hand guy") wherever he goes. Guy proves to be a charismatic athlete whose charm and self-confidence turn Jeff and Katie into better people overall.
- Steele Stebbins as Jeff Halsey and Guy
- Jay Larson as Mr. Halsey
- Julia Antonelli as Katie
- Lacianne Carriere as Oriole
- TBA as Mrs. Hilain